Design and Synthesis of an Efficient Nanophotosensitizer used in Photodynamic Therapy
Gold nanoparticle (GNP) was used for the delivery of a hydrophobic protoporphyrin IX (PpIX) as an efficient photosensitizer for photodynamic therapy. This conjugated GNPs were made by a single coupling reaction. Their optical properties indicate that PpIX-GNP conjugates could be used as a photosensitizer in photodynamic therapy (PDT) through the formulation of singlet oxygen. The GNP conjugates have an average diameter of 7 nm. Also, the ‘dark’ toxicity test of each of these individual components of these nanoparticles were carried on Hela cells.