Design and Synthesis of an Efficient Nanophotosensitizer used in Photodynamic Therapy

  • Neda Attaran Kakhki Science and Research Branch, Islamic Azad University
  • Hossein Eshghi 2Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436, Mashhad, Iran
  • Ameneh Sazgarnia Department of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mehdi Bakavoli 2Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436, Mashhad, Iran
  • Samaneh Soudmand Department of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Gold nanoparticle (GNP) was used for the delivery of a hydrophobic protoporphyrin IX (PpIX) as an efficient photosensitizer for photodynamic therapy. This conjugated GNPs were made by a single coupling reaction. Their optical properties indicate that PpIX-GNP conjugates could be used as a photosensitizer in photodynamic therapy (PDT) through the formulation of singlet oxygen. The GNP conjugates have an average diameter of 7 nm. Also, the ‘dark’ toxicity test of each of these individual components of these nanoparticles were carried on Hela cells.

Published
2018-01-24
How to Cite
ATTARAN KAKHKI, Neda et al. Design and Synthesis of an Efficient Nanophotosensitizer used in Photodynamic Therapy. Advances in Nanobiotechnology, [S.l.], v. 1, n. 1, p. 21-25, jan. 2018. Available at: <http://advnanotech.ir/index.php/advnanotech/article/view/7>. Date accessed: 15 sep. 2019.